Glass ampoules are still the most commonly used recepticles in which to store injection solutions.
The process of opening ampoules prior to use can pose a risk of contamination caused by poor aseptic technique, and also, by tiny fragments of glass being deposited in the solution.
Published data eminating from various Italian groups has made reference to this problem.
A further risk may be posed by the fact that glass splinters derive mainly from the external face of ampoules, which can carry an invisible layer of microbial contamination. Additionally, shelving or other surfaces on which ampoules are stored can harbour bacteria. Ampoules containing injection solution are subjected to repeated handling prior to use and therefore the opportunity for contamination to occur, in the process of preparing parenteral therapy cannot be ignored.
Contamination, caused by glass splinters or microbial infestation may contribute either in combination, or separately, to granulomatous lesions found in various organs of pareterally treated patients.